"... is the computational and mathematical modeling of complex biological systems. It is a biology-based interdisciplinary field of study that focuses on complex interactions within biological systems, using a holistic approach (holism instead of the more traditional reductionism) to biological research."

"As a field of study, particularly, the study of the interactions between the components of biological systems, and how these interactions give rise to the function and behavior of that system (for example, the enzymes and metabolites in a metabolic pathway or the heart beats)." (Wikipedia)

"What exactly is systems biology? Let me use the example of a systems approach towards analyzing how a car functions. First, one would use discovery science to identify all the different types of elements in a car—mechanical, electrical, and control. Second, one would formulate a preliminary model of how the car functions from prior knowledge. Third, one would drive, accelerate, brake, etc., the car and use global technologies to measure how all of the elements behaved with respect to one another under these various conditions. The behaviors of the different kinds of elements—mechanical, electrical, and control—would be integrated and compared to the model predictions. Hypothesis would be generated to explain the discrepancies between model predictions and experimental data and a second round of hypothesis driven, global analysis carried out and the results would be used to reformulate the model. This process would be repeated until the experimental data and the model were in agreement with one another.." (Leroy Hood)

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